Bone marrow failure syndromes denote rare disorders marked by a deficiency to produce enough blood – whether red cells, which transmit oxygen; white cells, which counters infection; or the tiny blood cells called platelets which aids your body to form clots so as to halt bleeding. Bone marrow failure ailments can be either hereditary or acquired. The inherited bone marrow failure syndromes (IBMFS) constitute a set of rare genetic blood ailment which involves some type of aplastic anemia or inability of the bone marrow to generate blood.
One such inherited bone marrow ailment is Diamond Blackfan Anemia (DBA) where the bone marrow is unable to form blood cells as a result DBA patients become extremely anemic. Bone marrow, as well as stem cells, make endocannabinoids which communicate with the cannabinoid receptors. The plant molecule CBD has been found to work upon these cannabinoid receptors and influence the body processes.
What Diamond Blackfan Anemia Means
Your red blood cells are formed within the spongy tissue inside the bones known as marrow. Diamond Blackfan Anemia (DBA) indicates a kind of anemia that results from a failure of the bone marrow to create sufficient red blood cells to meet the requirements of the body.
Causes Behind Diamond Blackfan Anemia
Diamond Blackfan anemia is generally diagnosed in children who are below one year of age. It results from alterations or mutations in the genes which are the building units of DNA. In some cases, the genetic mutation is transferred from a parent to the child. At times, the genes modify on its own. Almost half of DBA instances are linked to a genetic source, yet some others are not known to originate from a particular cause.
The gene that has been associated with this syndrome is situated on chromosome 19 and is called RPS19 (ribosomal protein 19).
Symptoms Associated With Diamond Blackfan Anemia
People suffering from DBA possess symptoms which are similar to various kinds of anemia and includes:
- Fatigue and weakness
- Pale skin
- prominent shoulder blades
- Short Stature
- Prominent facial abnormalities
- Abnormal shortening of the neck caused by the fusion of particular bones within the spine (cervical vertebrae)
- Hand deformities, for instance, abnormal thumbs
- Congenital heart abnormalities
The symptoms and physical results related to Blackfan-Diamond anemia differ from one case to another. People suffering from this type of bone marrow syndrome have a high deficiency of red blood cells but have normal platelet and white blood cell counts.
Cannabinoids Also Have Effects On The Cells
CBD has been used in the research of the stem cell and mutation of the gene CDKL5 causes a rare genetic ailment. Researchers have explored the existence of this gene in children affected by seizures, generally beginning from birth until two years old. The seizures arising from this ailment is hard to control and scientists are investigating to find the real cause though they are aware of the role played by this gene in managing the activities of other genes. Evidence from numerous trials has displayed that CBD effectively controls the proliferation, movement, and neurogenesis of MCSs or mesenchymal stem cells. The sample tissue containing the CDKL5 mutation was treated with CBD and the impact of cannabinoid was researched which paves the course for more beneficial treatments in the coming years.
People Using CBD Post Stem Cell Transplant
The results of a patient survey which was presented at the Annual Meeting of American Society of Clinical Oncology (ASCO) 2018 revealed that almost 20 percent of survivors of hematopoietic stem cell transplant have mentioned using CBD not only for easing physical and psychological side effects but due to the belief of its potential to heal their cancer. Some studies have shown the utility of CBD in curbing graft versus host ailment.
Further, findings analysing the function of the cannabinoid system in mesenchymal stem cell related tissue engineered cartilage restoration showed that stimulation of the cannabinoid system improves the survival and migration of MSCs and such findings reveal the power of the cannabinoids to perform a dual function by working as anti-inflammatory agents and regulation of MSC biology to help in cartilage repair.
Conclusion On CBD In Diamond Blackfan Anemia
The anti-inflammatory potential of CBD is helpful in safeguarding against diseases and is beneficial for stem cells. Moreover, CBD can trigger neurogenesis or the development of new neural cells and also surge the proliferation of new stem cells which gives it a cutting edge in treating bone marrow and stem cell growth.